Gregory A. Coffee

Mr. Coffee is a registered patent attorney with a practice spanning all areas of intellectual property. He has significant experience drafting patents in the fields of electrical, mechanical, automotive, chemical, and biomedical technologies, as well as preparing patentability opinions, and performing complex infringement analyses. In addition to prosecuting patents, Mr. Coffee is experienced in assisting clients with acquiring federal trademark protections, as well as enforcing their trademark rights, both domestically and abroad.

 

Prior to law school and throughout his studies, Mr. Coffee continued to pursue his career as a research scientist in the Department of Pediatric Pulmonology at Case Western Reserve University. Mr. Coffee gained over ten years of valuable experience as a researcher and has contributed to over twenty high-impact published manuscripts. His research has focused on several areas of discipline, including opioid induced respiratory depression, in which numerous novel therapeutics and implantable devices were tested in rodent models, genetic engineering, drug addiction and behavior modification, and modulation of the suprachiasmatic nucleus circadian clock.

 

While Mr. Coffee’s academic studies have focused extensively on medical physiology and biology, he is also skilled in drafting patent applications in the mechanical and electrical disciplines. His extensive hands-on work experience in the areas of automotive maintenance and technology, small engine repair, radio broadcasting, commercial and industrial electrical wiring, as well as aquatics instruction and management allow him a deep understanding of a wide variety of technologies developed by inventors.

 

Mr. Coffee was a proud member of the United States Navy at the Naval Special Warfare Command and remains an avid supporter of U.S. military members and their families.

 

Publications

1. Getsy PM, Coffee GA, Baby SM, May WJ, Henderson F Jr, Nakashe T, Knauss ZT, Forster HV, Hodges MR, Lewis SJ. 2025. The opioid receptor antagonist naloxonazine uncovers the pronounced ventilatory stimulant effects of fentanyl in freely-moving rats. Eur J Pharmacol. 1005:177925.

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2. Getsy PM, May W, Henderson F Jr, Coffee GA, Baby SM, Hsieh YH, Lewis SJ. 2025. Reversal of morphine-induced respiratory depression with the µ1-opioid receptor antagonist naloxonazine engenders excitation and instability of breathing. Am J Physiol Lung Cell Mol Physiol. 329(1):L97-L111.

 

3. Getsy PM, May WJ, Coffee GA, Baby SM, Hsieh YH, Bates JN, Lewis SJ. 2025. The ability of Ibutropin to blunt fentanyl-induced respiratory depression is independent of its activation of carotid body chemoafferents. J Pharmacol Exp Ther. 392(2):100060.

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4. Getsy PM, Coffee GA, Baby SM, May WJ, Henderson F Jr, Knauss ZT, Lewis SJ. 2025. The cystathionine-γ-lyase inhibitor DL-propargylglycine augments the ability of L-cysteine ethyl ester to overcome the adverse effects of morphine on breathing. Am J Physiol Lung Cell Mol Physiol. 328(6):L809-L825.

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5. Getsy PM, May WJ, Young AP, Baby SM, Lewis THJ, McShine A, Massien S, Coffee GA, Bates JN, Hsieh YH, Lewis SJ. 2025. Isobutyric tropine ester (Ibutropin) overcomes fentanyl-induced respiratory depression in unanesthetized rats without compromising analgesia. Neuropharmacology. 277:110479.

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6. Getsy PM, Coffee GA, Bates JN, Baby SM, Seckler JM, Palmer LA, Lewis SJ. 2025. Functional evidence that S-nitroso-L-cysteine may be a candidate carotid body neurotransmitter. Neuropharmacology. 265:110229.

 

7. Getsy PM, Coffee GA, Bates JN, Parran T, Hoffer L, Baby SM, MacFarlane P, Knauss ZT, Damron DS, Hsieh Y-H, Bubier JA, Mueller D, Lewis SJ. 2024. The cell-permeant antioxidant D-thiol ester D-cysteine ethyl ester overcomes physical dependence to morphine in male Sprague Dawley rats. Front. Pharmacol. 15:1444574.

 

8. Getsy PM, May WJ, Young AP, Baby SM, Coffee GA, Bates JN, Hsieh YH, Lewis SJ. 2024. Tropine exacerbates the ventilatory depressant actions of fentanyl in freely-moving rats. Front Pharmacol. 15:1405461.

 

9. Baby SM, May WJ, Getsy PM, Coffee GA, Nakashe T, Bates JN, Levine A, Lewis SJ. 2024. Fentanyl activates opposing opioid and non-opioid receptor systems that control breathing. Front Pharmacol. 5:1381073.

 

10. Getsy PM, Coffee GA, May WJ, Baby SM, Bates JN, Lewis SJ. 2024. The Reducing Agent Dithiothreitol Modulates the Ventilatory Responses That Occur in Freely Moving Rats during and following a Hypoxic-Hypercapnic Challenge. Antioxidants (Basel). 13(4):498.

 

11. Bates JN, Getsy PM, Coffee GA, Baby SM, MacFarlane PM, Hsieh YH, Knauss ZT, Bubier JA, Mueller D, Lewis SJ. 2024. Lipophilic analogues of D-cysteine prevent and reverse physical dependence to fentanyl in male rats. Front Pharmacol. 14:1336440.

 

12. Bates JN, Baby SM, Getsy PM, Coffee GA, Hsieh YH, Knauss ZT, Dahan A, Bubier JA, MacFarlane PM, Mueller D, Lewis SJ. 2024. L-NAC and L-NAC methyl ester prevent and overcome physical dependence to fentanyl in male rats. Sci Rep. 14(1):9091.

 

13. Baby SM, May WJ, Young AP, Wilson CG, Getsy PM, Coffee GA, Lewis THJ, Hsieh YH, Bates JN, Lewis SJ. 2024. L-cysteine ethylester reverses the adverse effects of morphine on breathing and arterial blood-gas chemistry while minimally affecting antinociception in unanesthetized rats. Biomed Pharmacother. 1:116081.

 

14. Getsy PM, Coffee GA, Kelley TJ, Lewis SJ. 2024. Male histone deacetylase 6 (HDAC6) knockout mice have enhanced ventilatory responses to hypoxic challenge. Front Physiol. 14:1332810.

 

15. Bates JN, Getsy PM, Coffee GA, Baby SM, MacFarlane PM, Hsieh YH, Knauss ZT, Bubier JA, Mueller D, Lewis SJ. 2023. L-cysteine ethyl ester prevents and reverses acquired physical dependence on morphine in male Sprague Dawley rats. Front Pharmacol. 14:1303207.

 

16. Getsy PM, Coffee GA, Lewis SJ. 2023. Loss of ganglioglomerular nerve input to the carotid body impacts the hypoxic ventilatory response in freely-moving rats. Front Physiol. 14:1007043.

 

17. Getsy PM, Davis J, Coffee GA, Lewis THJ, Lewis SJ. 2023. Hypercapnic signaling influences hypoxic signaling in the control of breathing in C57BL6 mice. J. Appl. Physiol. (1985). 134(5):1188-1206.

 

18. Getsy PM, Coffee GA, Hsieh YH, Lewis SJ. 2021. The superior cervical ganglia modulate ventilatory responses to hypoxia independently of preganglionic drive from the cervical sympathetic chain. J. Appl. Physiol. (1985). 131(2): 836–857.

 

19. Getsy PM, Coffee GA, Hsieh YH, Lewis SJ. 2021. Loss of Cervical Sympathetic Chain Input to the Superior Cervical Ganglia Affects the Ventilatory Responses to Hypoxic Challenge in Freely-Moving C57BL6 Mice. Front Physiol. 12: 619688.

 

20. Getsy PM, Coffee GA, Lewis SJ. 2020. The Role of Carotid Sinus Nerve Input in the Hypoxic-Hypercapnic Ventilatory Response in Juvenile Rats. Front Physiol. 11: 613786.

 

21. Getsy PM, Davis J, Coffee GA, May WJ, Palmer LA, Strohl KP, Lewis SJ. 2014. Enhanced non-eupneic breathing following hypoxic, hypercapnic or hypoxic-hypercapnic gas challenges in conscious mice. Respir. Physiol. Neurobiol. 1(204): 147–59.